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Searched for: [ Keywords: "Cancer network pharmacology" ] clear all
Journal Article
Role of Natural Products in Combating Cancer
by Camilla Barreto  and  Alwjandra Jandus
Abstract
Alternative bio actively chemicals may be found in natural goods and traditional herb medications, but only a few plant-information formulations have been rigorously studied and verified for their potential as medicinal therapies. The study of plant-derived elements' immunomodulation capabilities and their ability as provoke the immune system as combat various elemental disorde [...] Read more
Hit Affiliation:
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Switzerland.

Review
Role of macrophage polarization in cancer progression and their association with COVID-19 severity
by Abhimanyu Thakur , Rumpa Banerjee , Sudha Thakur , Gaurav Kumar  and  Shyam Sundar Thakur
Abstract
Macrophages are a type of white blood cells that can exist in two different functional states, known as M1 and M2. M1 macrophages secrete pro-inflammatory cytokines that can promote tumor growth and metastasis, whereas M2 macrophages secrete anti-inflammatory cytokines that can inhibit tumor progression. This phenomenon, referred to as macrophage polarization, has been implicat [...] Read more
Hit Affiliation:
Ben May Department for Cancer Research, Pritzker School of Molecular Engineering, University of Chicago, IL, USA.

Review
Unravelling the application of machine learning in cancer biomarker discovery
by Carter William , Choki Wangmo  and  Anjali Ranjan
Abstract
Machine learning is playing an increasingly important role in the healthcare industry by transforming the way cancer is diagnosed and treated. By analyzing patient data, genomic data, and imaging data, machine learning algorithms can identify molecular signatures that distinguish cancer patients from healthy patients. Biomarkers that can accurately detect and diagnose cancer ca [...] Read more

Journal Article
Special Healthcare Services for Lgbt Cancer Patients
by H. Mitchell  and  R. Jeffrey
Abstract
In the UK, a concern of prejudice, as well as a lack of gender identity and sexual orientation documentation, implies that LGBT persons mostly hidden to health-care providers. One of a review was carried out to examine primary literature on the psychological support requirements of LGBT cancer patients when receive treatment and after. Important findings: Key topics that have b [...] Read more

Review
Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity
by Sindhu Ramesh , Peyton Johnson , Khalda Fadlalla , Austin Moore , Chung-Hui Huang , Kristy Berry , Yulia Y Maxuitenko , Xi Chen , Adam B Keeton , Gang Zhou  and  Gary Piazza
Abstract
Approximately 28 million individuals in the United States face the risk of developing precancerous colonic adenomas (polyps) and potentially progressing to colorectal cancer (CRC). While a promising strategy for CRC prevention involves pharmacological intervention, such as cancer chemoprevention or interception, currently, there are no FDA-approved drugs capable of preventing t [...] Read more
Hit Affiliation:
Georgia Cancer Center, Augusta University, Augusta, GA, USA

Review
CRISPR-Cas9 Unleashed: Gene-Slicing Adventures in the Cancer Battlefield
by Shivakumar Sonnaila  and  Shilpi Agrawal
Abstract
Cancer, a global health menace, continues to pose significant challenges in terms of incidence and mortality, necessitating innovative therapeutic strategies. Despite existing treatments, the limitations persist, prompting a quest for novel approaches. The emergence of immunotherapy marked a transformative era in solid tumor treatments, yet its efficacy is constrained by advers [...] Read more

Review
The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements
by Yi Wu , Yanqi Li , Tong Wu  and  Hongmei Yang
Abstract
Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom of cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles in pathophysiological mechanisms in cancer, which is attracting great attention. However, there are still controversies about whether [...] Read more

Review
Cell membrane-coated nanoparticles for cancer therapy
by Yasir Hameed , Mohsen Nabi-Afjadi , Yuan Gu  and  Long Wu
Abstract
Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanopar [...] Read more

Review
Overcoming MTDH and MTDH-SND1 complex: driver and potential therapeutic target of cancer
by Hao Shen , Jiayu Ding , Jiaying Ji , Binjian Jiang , Xiao Wang  and  Peng Yang
Abstract
Metadherin (MTDH), also known as LYRIC or AEG-1, is an oncogene that enhances tumor progression, metastasis, drug resistance, and immune escape in various cancers by modulating multiple oncogenic pathways, including NF-κB, PI3K/AKT, Wnt/β-catenin, MAPK, and AMPK. Due to the unknown of the complete structure of MTDH, the deep mechanisms of MTDH and selective inhibitor [...] Read more

Review
E3 ubiquitin ligase-dependent regulatory mechanism of TRIM family in carcinogenesis
by Gui Zhang , Yunfang Zhang , Luxuan Chen , Langxia Liu  and  Xuejuan Gao
Abstract
Tripartite motif-containing (TRIM) proteins consist of over 80 proteins, the majority of which exhibit E3 ubiquitin ligase activity. E3 ligases have a critical role in various cellular processes by specifically recognizing and ubiquitinating substrate proteins to promote their proteasomal degradation or alter their activities. Numerous studies have indicated that TRIMs are invo [...] Read more

Journal Article
The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression
by Haitao Chen , Huilong Li , Wanjin Shi , Hai Qin  and  Lufeng Zheng
Abstract
As a reversible post-transcriptional modification, N6-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a subpopulation of cells with self-renewal ability and differentiation potential, have been regarded to be one of the roots of tumor occurrence, recurrence, and metastasis. Currently, numerous studies have dem [...] Read more

Journal Article
How Does Lncrna Regulation Impact Cancer Metastasis
by Abreto Devit Mancheng  and  Ugwemubwem Ossas
Abstract
Metastasis is the major cause of cancer-related mortality. Metastasis is a process through which cancer spreads from its initial location to other sections of the body. Cancer cells' epithelial-mesenchymal transition (EMT), anoikis resistance, cell migration, and angiogenesis are all well-known steps in this process. Investigating the molecular processes that govern cancer meta [...] Read more

Review
Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis
by Jincheng Wang , Jinyu Sun , Tao Qin , Xiaohan Ren , Jin Zhang  and  Xiaojie Lu
Abstract
The stages of liver fibrosis can reflect the severity of chronic viral hepatitis and the probability of liver cancer. Biopsy is still regarded as the reference for staging fibrosis, but the invasive method is not suitable for first-line screening. In recent years, noninvasive methods for detecting virus-driven liver fibrosis have been developed rapidly, which mainly include bio [...] Read more
Hit Affiliation:
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, 39216, USA

Review
Repurposing anti-parasite benzimidazole drugs as selective anti-cancer chemotherapeutics
by Fatemeh Movahedi , Li Li  and  Zhi Ping Xu
Abstract
Cancer chemotherapy is generally associated with many severe adverse effects. Many cancer studies are currently focused on repurposing conventional non-toxic anti-parasite drugs for cancer treatment. Since cancer cells and parasites have many features in common, some anti-parasite drugs such as benzimidazoles have been recently found to possess the anti-cancer activity. Benzimi [...] Read more

Journal Article
Drug Transport via Nanocarrier for Liver Cancer Treatment
by Shafirah Hussein  and  Jaffri Ruben
Abstract
The requirement of having multiple nanocarriers (NCs) and active agents for improved therapy, imaging, and controlled release of medications efficiently in one platform has made the creation of therapeutics and theragnostic nanodrug delivery systems a difficult task for present researchers. Multiple drug resistance (MDR), a high clearance rate, severe side effects, undesirable [...] Read more

Journal Article
Comprehensive analyses reveal molecular and clinical characteristics of RNA modification writers across 32 cancer types
by Jiayu Ding , Hao Shen , Jiaying Ji , Jiaxing Li , Wenbin Kuang , Zhongrui Shi , Dawei Wang , Yuanyuan Chen , Didi Wan , Xiao Wang  and  Peng Yang
Abstract
Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have pr [...] Read more

Review
Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review
by Dipro Mukherjee , Dibyajit Lahiri  and  Moupriya Nag
Abstract
Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radio [...] Read more

Review
Reassessing specificity/selectivity of taxane-based chemotherapy
by Elizabeth R. Smith , Zheshen Li , Zhe-Sheng Chen  and  Xiang-Xi Xu
Abstract
The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and [...] Read more
Hit Affiliation:
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA

Journal Article
Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development
by Zhengdong Yuan , Yiwen Zhang , Xuena Yang  and  Hai Qin
Abstract
Breast cancer, as a malignant tumor with easy metastasis and poor prognosis, threatens the health of women around the world. Increasing studies have shown that the Bcl-2 family of apoptosis-related proteins is often expressed abnormally in breast cancer. The Bcl-2 homology 3 (BH3) mimetic peptide can bind and neutralize Bcl-2, preventing its binding to the apoptosis "effector" [...] Read more

Journal Article
Bimetallic phosphidethe nanoparticles as photo-enhanced nanozymes for synergistic cancer immunotherapy
by Xingru Zhao
Abstract
Nanozyme with biomimetic enzyme activity has the advantages of good catalytic performance, high stability, and is not easily affected by temperature. However, the application of tumor microenvironment (TME) in the tumor is limited due to its low catalytic activity. Herein, a multifunctional nanozyme based on CuCoP with multivalent metal ions (Cu+/Cu2+ and Co2+/ Co3+) provides a [...] Read more