Open Access Review

Cell membrane-coated nanoparticles for cancer therapy

by Yasir Hameed a,1 orcid ,  Mohsen Nabi-Afjadi b,1 orcid ,  Yuan Gu c,* orcid  and  Long Wu d,* orcid
a
Department of Applied Biological Sciences, Tokyo University of Science, Tokyo, Japan
b
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
c
The Statistics Department, The George Washington University, Washington, United States
d
Department of Surgery, University of Maryland, Baltimore, United States
*
Author to whom correspondence should be addressed.
CI  2023, 23; 2(2), 23; https://doi.org/10.58567/ci02020007
Received: 15 June 2023 / Accepted: 28 June 2023 / Published Online: 29 June 2023
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Abstract

Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanoparticle surfaces yields Cell Membrane-coated Nanoparticles (CMNPs) that exhibit behavior akin to actual cells while offering superior structural robustness and stability. A variety of cell membranes, including those of red blood cells, white blood cells, and cancer cells, lend unique properties and targeting capabilities to CMNPs. This review outlines the diagnostic and therapeutic roles of CMNP-based drug delivery systems in oncology and contemplates their possible clinical impact.

Keywords: Cell membrane; Nanoparticles; Drug delivery; Cancer;
Copyright: © 2023 by Hameed, Nabi-Afjadi, Gu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Hameed, Y.; Nabi-Afjadi, M.; Gu, Y.; Wu, L. Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight, 2023, 2, 23. https://doi.org/10.58567/ci02020007
AMA Style
Hameed Y, Nabi-Afjadi M, Gu Y, Wu L. Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight; 2023, 2(2):23. https://doi.org/10.58567/ci02020007
Chicago/Turabian Style
Hameed, Yasir; Nabi-Afjadi, Mohsen; Gu, Yuan; Wu, Long 2023. "Cell membrane-coated nanoparticles for cancer therapy" Cancer Insight 2, no.2:23. https://doi.org/10.58567/ci02020007
APA style
Hameed, Y., Nabi-Afjadi, M., Gu, Y., & Wu, L. (2023). Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight, 2(2), 23. https://doi.org/10.58567/ci02020007

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