Open Access Review

Cell membrane-coated nanoparticles for cancer therapy

by Yasir Hameed a,1 orcid Mohsen Nabi-Afjadi b,1 orcid Yuan Gu c,* orcid  and  Long Wu d,* orcid
Department of Applied Biological Sciences, Tokyo University of Science, Tokyo, Japan
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
The Statistics Department, The George Washington University, Washington, United States
Department of Surgery, University of Maryland, Baltimore, United States
Author to whom correspondence should be addressed.
CI  2023, 23; 2(2), 23;
Received: 15 June 2023 / Accepted: 28 June 2023 / Published Online: 29 June 2023


Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanoparticle surfaces yields Cell Membrane-coated Nanoparticles (CMNPs) that exhibit behavior akin to actual cells while offering superior structural robustness and stability. A variety of cell membranes, including those of red blood cells, white blood cells, and cancer cells, lend unique properties and targeting capabilities to CMNPs. This review outlines the diagnostic and therapeutic roles of CMNP-based drug delivery systems in oncology and contemplates their possible clinical impact.

Copyright: © 2023 by Hameed, Nabi-Afjadi, Gu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Hameed, Y.; Nabi-Afjadi, M.; Gu, Y.; Wu, L. Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight, 2023, 2, 23.
AMA Style
Hameed Y, Nabi-Afjadi M, Gu Y, Wu L. Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight; 2023, 2(2):23.
Chicago/Turabian Style
Hameed, Yasir; Nabi-Afjadi, Mohsen; Gu, Yuan; Wu, Long 2023. "Cell membrane-coated nanoparticles for cancer therapy" Cancer Insight 2, no.2:23.
APA style
Hameed, Y., Nabi-Afjadi, M., Gu, Y., & Wu, L. (2023). Cell membrane-coated nanoparticles for cancer therapy. Cancer Insight, 2(2), 23.

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