Issue 2 (June)

Vol. 3 (2024), CI

6 articles

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Open Access Journal Article
LTBP1 promotes the progression of triple negative breast cancer via activating the RhoA/ROCK signaling pathway
by Jingcheng Zhang , Hong Deng  and  Jun Wang
CI  2023, 30; 3(2), 30; 10.58567/ci03020001 - 26 December 2023
The latent transforming growth factor-beta (TGF-β) binding protein 1 (LTBP1) has been implicated in various cellular processes, but its role in triple-negative breast cancer (TNBC) remains unclear. In this study, we investigated the impact of LTBP1 on TNBC progression and its underlying mechanisms. Analysis of online datasets revealed elevated LTBP1 mRNA expression in brea [...] Read more

Open Access Journal Article
Correlation between the immune microenvironment and bladder cancer based on a prognostic miRNA risk model
by Kun Mei , Zilu Chen , Le Huang , Joyce Wang  and  Yong Wei
CI  2024, 34; 3(2), 34; 10.58567/ci03020002 - 04 January 2024
Background: Bladder cancer (BLCA), particularly invasive BLCA, has become a medical burden worldwide as it is associated with recurrence and easy metastasis. There are specific differences in the expression of various miRNAs in tumor and normal tissues. Hence, miRNAs can be used as biomarkers for tumor diagnosis and prognostic evaluation. The current study aimed to predict the [...] Read more

Open Access Journal Article
A prognostic aging-related lncRNA risk model correlates with the immune microenvironment in HCC
by Kun Mei , Zilu Chen , Qin Wang , Akbar Ali , Yan Huang  and  Luo Yi
CI  2024, 35; 3(2), 35; 10.58567/ci03020003 - 09 January 2024
Background: Hepatocellular carcinoma (HCC) stands out as one of the most lethal cancers globally, given its complexity, recurrence following surgical resection, metastatic potential, and inherent heterogeneity. In recent years, researchers have systematically elucidated the significance of long non-coding RNA (lncRNA) in the initiation and progression of HCC. The intr [...] Read more
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Open Access Journal Article
Comprehensive analyses reveal molecular and clinical characteristics of RNA modification writers across 32 cancer types
by Jiayu Ding , Hao Shen , Jiaying Ji , Jiaxing Li , Wenbin Kuang , Zhongrui Shi , Dawei Wang , Yuanyuan Chen , Didi Wan , Xiao Wang  and  Peng Yang
CI  2024, 36; 3(2), 36; 10.58567/ci03020004 - 15 June 2024
Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have pr [...] Read more

Open Access Review
The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements
by Yi Wu , Yanqi Li , Tong Wu  and  Hongmei Yang
CI  2024, 37; 3(2), 37; 10.58567/ci03020005 - 15 June 2024
Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom of cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles in pathophysiological mechanisms in cancer, which is attracting great attention. However, there are still controversies about whether [...] Read more

Open Access Journal Article
Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development
by Zhengdong Yuan , Yiwen Zhang , Xuena Yang  and  Hai Qin
CI  2024, 38; 3(2), 38; 10.58567/ci03020006 - 15 June 2024
Breast cancer, as a malignant tumor with easy metastasis and poor prognosis, threatens the health of women around the world. Increasing studies have shown that the Bcl-2 family of apoptosis-related proteins is often expressed abnormally in breast cancer. The Bcl-2 homology 3 (BH3) mimetic peptide can bind and neutralize Bcl-2, preventing its binding to the apoptosis "effector" [...] Read more
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