Open Access Journal Article

Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development

by Zhengdong Yuan a Yiwen Zhang a Xuena Yang a  and  Hai Qin b,*
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
Department of Clinical Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 550014, China
Author to whom correspondence should be addressed.
CI  2024, 38; 3(2), 38;
Received: 6 January 2024 / Accepted: 22 March 2024 / Published Online: 2 April 2024


Breast cancer, as a malignant tumor with easy metastasis and poor prognosis, threatens the health of women around the world. Increasing studies have shown that the Bcl-2 family of apoptosis-related proteins is often expressed abnormally in breast cancer. The Bcl-2 homology 3 (BH3) mimetic peptide can bind and neutralize Bcl-2, preventing its binding to the apoptosis "effector" proteins Bak and Bax, thereby promoting the apoptosis process. However, there is a lack of effective intracellular delivery system for BH3 to exert its biological activity. Therefore, this study utilized an activatable supercharged polypeptide (ASCP) tumor-targeted delivery platform based on pH and protease response to achieve the targeted release of BH3 at the tumor site. Ultimately, intracellular delivery of BH3 was achieved and induced apoptosis of breast tumor cells, preventing the development of breast cancer.

Copyright: © 2024 by Yuan, Zhang, Yang and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Yuan, Z.; Zhang, Y.; Yang, X.; Qin, H. Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development. Cancer Insight, 2024, 3, 38.
AMA Style
Yuan Z, Zhang Y, Yang X, Qin H. Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development. Cancer Insight; 2024, 3(2):38.
Chicago/Turabian Style
Yuan, Zhengdong; Zhang, Yiwen; Yang, Xuena; Qin, Hai 2024. "Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development" Cancer Insight 3, no.2:38.
APA style
Yuan, Z., Zhang, Y., Yang, X., & Qin, H. (2024). Targeted intracellular delivery of BH3 mimetic peptide inhibits BCL-2 activity and prevents breast cancer development. Cancer Insight, 3(2), 38.

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