Cancer Insight

oa Open Access

E-ISSN: 2972-3388

Cancer Insight (CI) is an open access, peer-reviewed journal with broad scope covering all areas of cancer research, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer.  Cancer Insight aims to disseminate and communicate scientific advancement and impactful discoveries on the field of oncology to researchers, academics, clinicians, and the public worldwide. 

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Open Access Review
Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity
by Sindhu Ramesh , Peyton Johnson , Khalda Fadlalla , Austin Moore , Chung-Hui Huang , Kristy Berry , Yulia Y Maxuitenko , Xi Chen , Adam B Keeton , Gang Zhou  and  Gary Piazza
CI 2023, 2 (2); 10.58567/ci02020003 - 30 November 2023
Abstract
Approximately 28 million individuals in the United States face the risk of developing precancerous colonic adenomas (polyps) and potentially progressing to colorectal cancer (CRC). While a promising strategy for CRC prevention involves pharmacological intervention, such as cancer chemoprevention or interception, currently, there are no FDA-approved drugs capable of preventing t [...] Read more
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Open Access Review
Reassessing specificity/selectivity of taxane-based chemotherapy
by Elizabeth R. Smith , Zheshen Li , Zhe-Sheng Chen  and  Xiang-Xi Xu
CI 2023, 2 (2); 10.58567/ci02020002 - 29 November 2023
Abstract
The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and [...] Read more
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Open Access Review
Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements
by Chunfeng Liu  and  Lei Ren
CI 2023, 2 (2); 10.58567/ci02020001 - 29 November 2023
Abstract
Ferroptosis, a recently identified form of programmed cell death, is characterized by the accumulation of lipid peroxidation, reactive oxygen species, and elevated free iron levels, involving the regulation of glutathione metabolism, iron metabolism, lipid metabolism, and oxidative stress biology. Tumor metastasis, a critical hallmark of malignancy and a key contributor to canc [...] Read more

Open Access Review
Cell membrane-coated nanoparticles for cancer therapy
by Yasir Hameed , Mohsen Nabi-Afjadi , Yuan Gu  and  Long Wu
CI 2023, 2 (1); 10.58567/ci02010009 - 29 June 2023
Abstract
Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanopar [...] Read more
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Open Access Journal Article
Mechanism of congenital lymphocytes and intestinal immunity regulated by gut microbial metabolites via metabolite-sensing receptor Ffar2
by Chen Deng
CI 2023, 2 (1); 10.58567/ci02010008 - 28 June 2023
Abstract
Objective: The DSS was utilized to construct colitis model of mouse. The colitis mice were colonized with gut microbiota. The effects of gut microbial metabolites on colitis were studied. The mechanisms of gut microbial metabolites to improve intestinal immunity were also further explored. Methods: The male BALB/c mice were selected to construct colitis mouse model with DSS and [...] Read more
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Open Access Review
E3 ubiquitin ligase-dependent regulatory mechanism of TRIM family in carcinogenesis
by Gui Zhang , Yunfang Zhang , Luxuan Chen , Langxia Liu  and  Xuejuan Gao
CI 2023, 2 (1); 10.58567/ci02010007 - 28 June 2023
Abstract
Tripartite motif-containing (TRIM) proteins consist of over 80 proteins, the majority of which exhibit E3 ubiquitin ligase activity. E3 ligases have a critical role in various cellular processes by specifically recognizing and ubiquitinating substrate proteins to promote their proteasomal degradation or alter their activities. Numerous studies have indicated that TRIMs are invo [...] Read more
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Open Access Review
Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects
by Hongmei Yang , Chen Li  and  Qiang Xie
CI 2023, 2 (1); 10.58567/ci02010006 - 28 June 2023
Abstract
Nanomaterials have shown great potential in anti-tumor applications and are currently the focus of research. This review article aims to provide a comprehensive overview of the challenges encountered in oncology treatment and how nanomaterials are being utilized to overcome these obstacles. The authors discuss the limitations of conventional treatments, including limited effica [...] Read more
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Open Access Review
Role of macrophage polarization in cancer progression and their association with COVID-19 severity
by Abhimanyu Thakur , Rumpa Banerjee , Sudha Thakur , Gaurav Kumar  and  Shyam Sundar Thakur
CI 2023, 2 (1); 10.58567/ci02010005 - 25 June 2023
Abstract
Macrophages are a type of white blood cells that can exist in two different functional states, known as M1 and M2. M1 macrophages secrete pro-inflammatory cytokines that can promote tumor growth and metastasis, whereas M2 macrophages secrete anti-inflammatory cytokines that can inhibit tumor progression. This phenomenon, referred to as macrophage polarization, has been implicat [...] Read more
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Open Access Review
Liver fibrosis from viral hepatitis: advances in non-invasive diagnosis
by Jincheng Wang , Jinyu Sun , Tao Qin , Xiaohan Ren , Jin Zhang  and  Xiaojie Lu
CI 2023, 2 (1); 10.58567/ci02010002 - 14 June 2023
Abstract
The stages of liver fibrosis can reflect the severity of chronic viral hepatitis and the probability of liver cancer. Biopsy is still regarded as the reference for staging fibrosis, but the invasive method is not suitable for first-line screening. In recent years, noninvasive methods for detecting virus-driven liver fibrosis have been developed rapidly, which mainly include bio [...] Read more
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Open Access Journal Article
Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation
by Suleyman ILHAN
CI 2023, 2 (1); 10.58567/ci02010004 - 14 June 2023
Abstract
Although docetaxel treatment yields a high survival rate for prostate cancer (PCa), resistance eventually develops in many patients. Understanding the underlying mechanisms of docetaxel resistance is essential for improving treatment strategies. Cytokines, which play a role in cell signaling and immune responses, have been implicated in drug resistance mechanisms. The study rev [...] Read more
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