Open Access Journal Article

Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation

by Suleyman ILHAN a,* orcid
a
Manisa Celal Bayar University, Faculty of Science and Letters, Biology Department Manisa,Türkiye
*
Author to whom correspondence should be addressed.
CI  2023, 18; 2(1), 18; https://doi.org/10.58567/ci02010004
Received: 20 May 2023 / Accepted: 7 June 2023 / Published Online: 14 June 2023
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Abstract

Although docetaxel treatment yields a high survival rate for prostate cancer (PCa), resistance eventually develops in many patients. Understanding the underlying mechanisms of docetaxel resistance is essential for improving treatment strategies. Cytokines, which play a role in cell signaling and immune responses, have been implicated in drug resistance mechanisms. The study revealed that interleukin-8 (IL-8) was consistently overexpressed in both docetaxel-resistant PCa cell lines. Thus, the expression levels of cytokines released from docetaxel-sensitive (PC-3- and DU-145) and resistant (PC-3/R-DU-145/R) PCa cells were compared. IL-8 was found to be commonly expressed in resistant cell lines. This finding led to the hypothesis that IL-8 could play a key role in mediating PCa cell resistance to docetaxel. IL-8 siRNA treatment increased docetaxel sensitivity in both resistant cells. To demonstrate the mechanism of IL-8-related resistance, MDR1 expression was evaluated. After IL-8 siRNA treatment MDR1 expression was reduced in both resistant cells suggesting that IL-8 regulates the docetaxel resistance of PCa cells via modulation of multidrug resistance 1 (MDR1). By expanding the knowledge of the cytokines and their effect mechanisms, novel approaches can be developed for the treatment of docetaxel-resistant prostate cancer. Further investigations into the role of IL-8 in docetaxel resistance could offer valuable insights into the development of effective treatment strategies for PCa patients.

Keywords: Docetaxel resistance; Cytokine; IL-8; Prostate cancer; MDR1;
Copyright: © 2023 by ILHAN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
ILHAN, S. Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation. Cancer Insight, 2023, 2, 18. https://doi.org/10.58567/ci02010004
AMA Style
ILHAN S. Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation. Cancer Insight; 2023, 2(1):18. https://doi.org/10.58567/ci02010004
Chicago/Turabian Style
ILHAN, Suleyman 2023. "Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation" Cancer Insight 2, no.1:18. https://doi.org/10.58567/ci02010004
APA style
ILHAN, S. (2023). Effect of interleukin-8 on docetaxel resistance in prostate cancer cells: insights into the role of multidrug resistance 1 protein modulation. Cancer Insight, 2(1), 18. https://doi.org/10.58567/ci02010004

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