Issue 1 (March)

Vol. 3 (2024), CI

6 articles

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Open Access Review
Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements
by Chunfeng Liu  and  Lei Ren
CI  2023 3(1):26; 10.58567/ci03010001 - 29 November 2023
Abstract
Ferroptosis, a recently identified form of programmed cell death, is characterized by the accumulation of lipid peroxidation, reactive oxygen species, and elevated free iron levels, involving the regulation of glutathione metabolism, iron metabolism, lipid metabolism, and oxidative stress biology. Tumor metastasis, a critical hallmark of malignancy and a key contributor to canc [...] Read more

Open Access Review
Reassessing specificity/selectivity of taxane-based chemotherapy
by Elizabeth R. Smith , Zheshen Li , Zhe-Sheng Chen  and  Xiang-Xi Xu
CI  2023 3(1):27; 10.58567/ci03010002 - 29 November 2023
Abstract
The paramount prerequisite for effective anti-cancer drugs is their ability to eradicate malignant cells while sparing non-cancer cells. The divergence in properties between malignant and non-cancer cells establishes a "therapeutic window," a critical consideration for achieving desirable treatment outcomes. Central to this is the imperative of a cancer drug's "selectivity and [...] Read more
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Open Access Review
Novel sulindac derivatives for colorectal cancer chemoprevention that target cGMP phosphodiesterases to suppress Wnt/β-catenin transcriptional activity
by Sindhu Ramesh , Peyton Johnson , Khalda Fadlalla , Austin Moore , Chung-Hui Huang , Kristy Berry , Yulia Y Maxuitenko , Xi Chen , Adam B Keeton , Gang Zhou  and  Gary Piazza
CI  2023 3(1):28; 10.58567/ci03010003 - 30 November 2023
Abstract
Approximately 28 million individuals in the United States face the risk of developing precancerous colonic adenomas (polyps) and potentially progressing to colorectal cancer (CRC). While a promising strategy for CRC prevention involves pharmacological intervention, such as cancer chemoprevention or interception, currently, there are no FDA-approved drugs capable of preventing t [...] Read more
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Open Access Review
Overcoming MTDH and MTDH-SND1 complex: driver and potential therapeutic target of cancer
by Hao Shen , Jiayu Ding , Jiaying Ji , Binjian Jiang , Xiao Wang  and  Peng Yang
CI  2023 3(1):29; 10.58567/ci03010004 - 11 December 2023
Abstract
Metadherin (MTDH), also known as LYRIC or AEG-1, is an oncogene that enhances tumor progression, metastasis, drug resistance, and immune escape in various cancers by modulating multiple oncogenic pathways, including NF-κB, PI3K/AKT, Wnt/β-catenin, MAPK, and AMPK. Due to the unknown of the complete structure of MTDH, the deep mechanisms of MTDH and selective inhibitor [...] Read more
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Open Access Review
Research progress of nanomedicine for tumor immunotherapy
by Xingyi Wan , Mengyan Jiang  and  Shriya Madan
CI  2023 3(1):31; 10.58567/ci03010005 - 28 December 2023
Abstract
Cancer, a pervasive threat to human health, presents formidable challenges to traditional treatment approaches. Tumor immunotherapy has emerged as a promising strategy for combating malignancies by bolstering the body's immune response to thwart tumor metastasis and recurrence. Nonetheless, the intricacies of tumors, patient heterogeneity, and the presence of tumor-immunosuppre [...] Read more
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Open Access Review
Exploring Longitudinal MRI-Based Deep Learning Analysis in Parkinson’s Patients - A Short Survey Focus on Handedness
by Yuan Gu , Ziyang Wang , Yuli Wang , Yishu Gong  and  Chen Li
CI  2023 3(1):32; 10.58567/ci03010006 - 28 December 2023
Abstract
Parkinson’s Disease (PD) is a prevalent progressive neurodegenerative condition affecting millions globally. Research has found that individuals with PD have a reduced risk of certain cancers, such as colon, lung, and rectal cancers, but an increased risk of brain cancer. Therefore, there is an urgent need for the development of advanced PD diagnostic methods and for inve [...] Read more
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