Open Access Review

Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements

by Chunfeng Liu a  and  Lei Ren b,*
a
Institute of Pathology, Faculty of Medicine, Ludwig Maximilians University of Munich, Munich, Germany.
b
Klinikum rechts der Isar, Faculty of Medicine, Technical University of Munich, Munich, Germany.
*
Author to whom correspondence should be addressed.
CI  2023, 26; 3(1), 26; https://doi.org/10.58567/ci03010001
Received: 13 November 2023 / Accepted: 28 November 2023 / Published Online: 29 November 2023
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Abstract

Ferroptosis, a recently identified form of programmed cell death, is characterized by the accumulation of lipid peroxidation, reactive oxygen species, and elevated free iron levels, involving the regulation of glutathione metabolism, iron metabolism, lipid metabolism, and oxidative stress biology. Tumor metastasis, a critical hallmark of malignancy and a key contributor to cancer recurrence and mortality, has been extensively linked to iron dysregulation, highlighting the potential of agents inducing iron-mediated cell death as promising strategies for preventing and treating metastasis. This review offers a comprehensive understanding the regulatory mechanisms underlying ferroptosis and its crucial role in the three distinct stages of metastasis: invasion, circulation, and colonization.

Keywords: Ferroptosis; Lipid peroxidation; Tumor metastasis; Iron; Glutathione metabolism; Reactive oxygen species;
Copyright: © 2023 by Liu and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Liu, C.; Ren, L. Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements. Cancer Insight, 2024, 3, 26. https://doi.org/10.58567/ci03010001
AMA Style
Liu C, Ren L. Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements. Cancer Insight; 2024, 3(1):26. https://doi.org/10.58567/ci03010001
Chicago/Turabian Style
Liu, Chunfeng; Ren, Lei 2024. "Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements" Cancer Insight 3, no.1:26. https://doi.org/10.58567/ci03010001
APA style
Liu, C., & Ren, L. (2024). Enhanced understanding of the involvement of ferroptosis in tumorigenesis: A review of recent research advancements. Cancer Insight, 3(1), 26. https://doi.org/10.58567/ci03010001

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