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Open Access Journal Article

Noninvasive Deep-Tissue Temperature Monitoring Based on Magnetic Mediated Thermoacoustics

by Siyu Liu a,b,*
Southwest Institute of Technical Physics, Chengdu, Sichuan 610041, China
School of Science, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China
Author to whom correspondence should be addressed.
BAB  2022, 5; 1(1), 5;
Received: 15 November 2022 / Accepted: 12 December 2022 / Published: 26 December 2022


Noninvasive acquisition of deep tissue temperature has important applications in home health monitoring, hyperthermia safety control, and other domains. In this work, we present here a novel magnetically mediated thermoacoustic temperature measurement method. Utilizing coil to stimulate amplitude modulated magnetic field and ultrasound transducer to receive the generated thermoacoustic wave from the inserted magnetic nanoparticles. Benefiting from the high sensitivity of thermoacoustic emission from nanoparticles and the deep penetration capability of both magnetic field and ultrasound propagation, the proposed thermoacoustic temperature measurement system enables a high measurement accuracy of 0.5 degrees Celsius in real time. This work potentially facilitates further development of closed loop magnetic hyperthermia for practical clinical applications.

Copyright: © 2022 by Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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National Natural Science Foundation of China (12204242) , Natural Science Foundation of Jiangsu Province (BK20210323)

Share and Cite

ACS Style
Liu, S. Noninvasive Deep-Tissue Temperature Monitoring Based on Magnetic Mediated Thermoacoustics. Biomaterials and Biosensors, 2022, 1, 5.
AMA Style
Liu S. Noninvasive Deep-Tissue Temperature Monitoring Based on Magnetic Mediated Thermoacoustics. Biomaterials and Biosensors; 2022, 1(1):5.
Chicago/Turabian Style
Liu, Siyu 2022. "Noninvasive Deep-Tissue Temperature Monitoring Based on Magnetic Mediated Thermoacoustics" Biomaterials and Biosensors 1, no.1:5.
APA style
Liu, S. (2022). Noninvasive Deep-Tissue Temperature Monitoring Based on Magnetic Mediated Thermoacoustics. Biomaterials and Biosensors, 1(1), 5.

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  1. Pouch M. A., Theodore W. C., Susan M. S., and Chandra M. S.. “In Vivo Noninvasive Temperature Measurement by B-Mode Ultrasound Imaging.” Journal of Ultrasound in Medicine 29, no. 11 (2010): 1595–1606.
  2. Guo, Shoujing, Shuwen Wei, Soohyun Lee, Mary Sheu, Sewon Kang, and Jin U. Kang. “Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring during Cutaneous Laser Therapy.” IEEE Journal of Translational Engineering in Health and Medicine 7 (2019): 1–8.
  3. Pramanik Manojit, and Lihong V. Wang. “Thermoacoustic and Photoacoustic Sensing of Temperature.” Journal of Biomedical Optics 14, no. 5 (2009): 054024.
  4. Liu Siyu, Xiaohua Feng, Haoran Jin, Ruochong Zhang, Yunqi Luo, Zesheng Zheng, Fei Gao, and Yuanjin Zheng. “Handheld Photoacoustic Imager for Theranostics in 3D.” IEEE Transactions on Medical Imaging 38, no. 9 (2019): 2037–46.
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  6. Feng, Xiaohua, Fei Gao, and Yuanjin Zheng. “Magnetically Mediated Thermoacoustic Imaging toward Deeper Penetration.” Applied Physics Letters 103, no. 8 (2013): 083704.
  7. Liu Siyu, Weitao Song, Xinqin Liao, Tony Tae-Hyoung Kim, and Yuanjin Zheng. “Development of a Handheld Volumetric Photoacoustic Imaging System with a Central-Holed 2D Matrix Aperture.” IEEE Transactions on Biomedical Engineering 67, no. 9 (2020): 2482–89.
  8. Liu Siyu, Ruochong Zhang, Zesheng Zheng, and Yuanjin Zheng. “Electromagnetic–Acoustic Sensing for Biomedical Applications.” Sensors 18, no. 10 (2018): 3203.
  9. Liu Siyu, Xiaohua Feng, Zhang Ruochong, and Yuanjin Zheng. “Portable Photoacoustic System for Noninvasive Blood Temperature Measurement.” 2018 IEEE International Symposium on Circuits and Systems (ISCAS), 2018.
  10. Liu Siyu, Ruochong Zhang, Yunqi Luo, and Yuanjin Zheng. “Magnetoacoustic Microscopic Imaging of Conductive Objects and Nanoparticles Distribution.” Journal of Applied Physics 122, no. 12 (2017): 124502.