In the UK, a concern of prejudice, as well as a lack of gender identity and sexual orientation documentation, implies that LGBT persons mostly hidden to health-care providers. One of a review was carried out to examine primary literature on the psychological support requirements of LGBT cancer patients when receive treatment and after. Important findings: Key topics that have been mentioned include the negative impact on mental health, health care professional education and the absence of inclusive support groups, the pervasiveness of discriminatory practices within healthcare services. The research demonstrates how LGBT cancer patients are being failed by healthcare professionals in terms of psychological support, resulting in unmet requirements. There are some suggestions use to guarantee an LGBT inclusive atmosphere in cancer care, as well as the development of support programmes for LGBT people with cancer. Practical connotation: LGBT wellness and awareness education should be offered for HCP personnel. The registration and tracking of gender identity and sexual orientation is critical to ensuring that LGBT persons are not 'invisible' in cancer, radiation, and continued studies. LGBT cancer groups and services should be established, since information from the study indicated that LGBT individuals are actively seeking these services.
Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.
Bank capital requirements would entail large social costs if they made resource allocation suboptimal and banking services costly by unduly limiting the banks’ ability to lend. This paper considers three main factors that may make capital requirements relevant, namely, deposit insurance subsidies, stock valuation errors, and tax shields derived from debt financing. The theoretical model analyzes the combined effects of the three factors on the banks’ incentives to make fairly priced loans, which should also be socially optimal loans. A key finding is that the long-term cost of capital requirements is likely to be very small when deposit insurance is underpriced. Increased funding costs resulting from higher capital requirements are absorbed by shareholders of banks, rather than passed on to borrowers. Under some reasonable assumptions, higher capital requirements improve resource allocation by countervailing distortionary effects of deposit insurance subsidies. Short-term adjustment costs can still be large, but it should be relatively easy to mitigate the short-term effects.
Based on fully considering the actual differences in statistical indicators between Hong Kong, Macao, and the nine cities in the Pearl River Delta, this paper constructs a high-quality urban development evaluation system that is suitable for the actual development of the Guangdong-Hong Kong-Macao Greater Bay Area. The Entropy Weighted TOPSIS two-step method is used to process data and systematically investigate the changes in the high-quality development index of 11 cities in the Guangdong-Hong Kong-Macao Greater Bay Area from 2013 to 2020. The study found that the Guangdong-Hong Kong-Macao Greater Bay Area has thoroughly implemented the new development concept, and the level of high-quality development has continued to improve. The profound integration effect of the Guangdong-Hong Kong-Macao Greater Bay Area has appeared, and it has promoted the high-quality development of the region in coordination. The construction of the Guangdong-Hong Kong-Macao Greater Bay Area has strongly promoted the great practice of "one country, two systems" to achieve stability and prosperity.
Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydroxides. It has a series of unique properties, such as high conductivity, metalloid properties, a variety of valence states and adjustable structure and so on. These advantages make it have great potential in biomedical applications, such as diagnostic imaging, disease therapy and drug/gene delivery. This review presents the latest research progress of TMS/TMP on tumor imaging, diagnosis and treatment. Here, we first illustrate the synthesis approaches and surface modification of TMS/TMP. Then, its emerging applications in tumor diagnosis and therapy are highlighted. Moreover, the challenges of TMS/TMP-mediated diagnosis/treat are provided and the prospective for this field are discussed.
With the improvement of people's living standards and the increasing emphasis on health, new and higher demands are also placed on the medical industry. The diagnosis and treatment methods combining artificial intelligence and medicine are bound to receive more and more attention and promotion. At present, drug design is stepping into the era of artificial intelligence, and academia and industry are actively applying artificial intelligence technology to all aspects of drug research and development, including drug screening, molecular characterization, drug activity and druggability optimization, chemical reaction design, etc. Relying on the big data information of millions of patients, the artificial intelligence system can quickly and accurately mine and screen out suitable drugs. Through computer simulations, artificial intelligence can make predictions about drug activity, safety, and side effects, and find the best drug that matches the disease. This technology will shorten the drug development cycle, reduce the cost of new drugs and improve the success rate of new drug development.
In the past, researchers investigated the immune response acting against mycobacterial antigens in tuberculosis (TB). Several ELISA tests have been conducted for the diagnosis of tuberculosis. Other researchers manipulated 16 kDa antigen from Mycobacterium Tuberculosis to develop a tuberculosis diagnostic test while some others studied the subspecies of M. tuberculosis. In the present study, we explored the possibilities of detecting 16 kDa protein derived from M. tuberculosis, on an interdigitated electrode (IDE). Measurements with Electrochemical impedance spectroscopy and current-volt systems were demonstrated using antibody as the probe. Further, the involvement of gold nanoparticle for the signal-enhancement and high-performance are evidenced. The specificity in the serum containing samples is used to show the clinical relevancy. 16 kDa antigen used in this experiment is highly reliable for TB diagnosis as it largely expresses and can be implemented in other sensing system.
Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy，chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.
Noninvasive acquisition of deep tissue temperature has important applications in home health monitoring, hyperthermia safety control, and other domains. In this work, we present here a novel magnetically mediated thermoacoustic temperature measurement method. Utilizing coil to stimulate amplitude modulated magnetic field and ultrasound transducer to receive the generated thermoacoustic wave from the inserted magnetic nanoparticles. Benefiting from the high sensitivity of thermoacoustic emission from nanoparticles and the deep penetration capability of both magnetic field and ultrasound propagation, the proposed thermoacoustic temperature measurement system enables a high measurement accuracy of 0.5 degrees Celsius in real time. This work potentially facilitates further development of closed loop magnetic hyperthermia for practical clinical applications.
We analyze the annual microdata of China's 100 commercial banks from 2007 to 2018 using the mediating effect analysis method, analyze the negative impact of economic policy uncertainty on the credit scale of commercial banks, and then verify the intermediary effects of the operational risks and short-term capital liquidity of commercial banks in the impact of economic policy uncertainty on the scale of commercial bank credit, separately. Moreover, we find that non-state-owned commercial banks, large-scale commercial banks, low-leverage commercial banks, and commercial banks with low profitability are more susceptible to economic policy uncertainty affecting commercial bank credit growth through short-term capital liquidity, and vice versa.
We empirically address the effects of monetary policy on the housing market in China using a novel Time-Varying Parameter VARX model. We show that an expansionary monetary has positive effects on the housing market, while during COVID-19, the effects are approaching to zero or even negative. In addition, the effects of the LPR policy are strong and even larger than that of COVID-19. Relative impulse response functions in the shorter and longer time horizons are dynamic and especially during COVID. This paper also contributes to the housing literature to show that COVID-19 can block the transmission of monetary policy.
By introducing time to build, which creates a time-lag between government investment and the accumulation of productive capital, into an analysis of fiscal stimulus to the economy with financial frictions, we find that the effectiveness of fiscal policy is dampened. While the weakening effects of time to build become significantly weaker alongside with a higher fraction of government bonds allocated to leverage-constrained banks, which can be explained by a high correlation between time to build and financial frictions in both worsening balance sheet conditions of banks. Furthermore, the stimulus effects of public investment become stronger associated with shorter time-to-build period.
Based on the empirical data of 6110 listed export companies in China from 2010 to 2019, this paper studies the impact of China's economic policy uncertainty (EPU) index on the profitability of listed companies from the specific perspective of export companies, and analyzes the moderating effects of different factors on this impact. The results show that China's EPU index has a significant negative impact on the profitability of listed export companies, and the increase in R&D investment and wage returns will aggravate this negative impact. In addition, listed export enterprises with different enterprise characteristics have different responses to EPU. State-owned enterprises and enterprises located in coastal areas are relatively less negatively affected by EPU.
We employ the joint production decomposition model to conduct a full decomposition of CO2 emission among 36 industrial sectors in China from 1998 to 2011, under the framework of growth accounting. The results show that: (1) the average CO2 emission increases at an annual rate of 3.01%, and production technology progression is the main driving force, while the transformation toward clean production effectively curb the rapid growth of CO2 emissions; (2) the effect of technology changes on CO2 emission is larger during the "10th Five-Year Plan" compared with the "11th Five-Year Plan", which makes the annual growth rate of CO2 emission during the "11th Five-Year Plan" 1% lower than its counterpart; This study has important theoretical and practical significance for understanding the driving factors of CO2 emission and the corresponding emission reduction measures.
Based on provincial panel data from 1998-2018, this paper estimates research and development (R&D) factors, and a stochastic frontier analysis (SFA) model is constructed to examine the effects of R&D factors on regional total factor productivity (TFP). The results show that both R&D capital stock and R&D personnel can significantly promote regional TFP, but the productivity-enhancing effect of R&D factors is different between regions. Specifically, R&D capital and R&D personnel can promote TFP in eastern and central provinces, and the promotion effect is not significant in western provinces. In addition, compared with investment-driven regions, innovation-driven regions are more likely to enhance TFP by R&D factors.
The implementation of environmental protection strategy necessarily requires mapping the amount of capital stock of environmental infrastructure. Through the Weibull distribution function and hyperbolic age-decreasing efficiency model, the provincial environmental infrastructure capital stock in China from 1980 to 2018 is measured cautiously, and its spatial dynamics with the generated pollutants is analyzed using the center of gravity method. It is found that: the spatial distribution of environmental infrastructure capital stock is uneven, and the unevenness in the east-west direction is greater than that in the north-south direction, but the unevenness in the east-west direction is narrowing while the north-south direction is widening; the spatial and temporal distribution of environmental infrastructure capital and environmental pollution vary greatly, and the spatial management of environmental pollution is less accurate.
This study simultaneously tests Wagner’s law on one hand and Keynes proposition on the other hand related both government spending and output in Ivory Coast that experiencing long run economic growth and widened deficit. That challenges the country’s fiscal sustainability. With annual data from 1980 to 2020, results show that Wagner’s law holds, the elasticity of government spending to output is greater than one. There is bidirectional causality between government size and output validating Keynesian idea that public expenditure is an exogenous factor and a policy instrument for increasing national income. Wagner law and public deficit can justify Ivorian over-indebtedness.
With the daily data from Nov 20, 2019 to Oct 31, 2022, this paper examines the dynamic nonlinear effects of RCEP on Dual Circulation and Greater Bay Area stock market from a quantile perspective. The rolling window quantile regressions detect the positive effects of RCEP on Dual Circulation and Greater Bay Area stock markets with significant time-varying characteristics. Meanwhile, QQ results show that the impacts from RCEP index are more significant under extreme conditions. In addition, we further use a nonparametric QC test to provide evidence on the predictive power of RCEP for Dual Circulation and Greater Bay Area with stock market.
In order to avoid the real economy development lags behind and the deterioration of ecological problems in the process of traditional urbanization, China has been promoting city-industry deep integration, but the connection between city-industry integration and green economic growth, especially the spatial effect, has not been systematically explained. Based on the panel data from 2007 to 2018, this paper constructs an evaluation index system and uses the SEEA method to measure city-industry integration (CII) level and green economy growth (GEG) level. Then, by employing spatial Durbin model and intermediary effect model, it further systematically investigates the spatial impact of CII on GEG and the potential mechanism. The study found that: (1) On the whole, CII shows “slow-steady integration” trend, but regional heterogeneity was obvious and accompanied by “slow gap expansion”. GEG experienced “sharp increase” with “polarization” characteristic. (2) CII can directly promote regional GEG (with a marginal effect of 0.689), more effectively than traditional urbanization, and CII has obvious spatial spillover effects on GEG in both “local effect” and “neighboring effect”. (3) Interestingly, technological innovation and consumption structure upgrading are significant mediating mechanisms. (4) The direct positive effect of CII shows the regional imbalance characteristic. Finally, the corresponding policy implications are put forward.
Based on the panel data of western central-cities from 2002 to 2021, this paper uses the intermediary effect model to analyze the relationship between urban internationalization, innovation ability and urban competitiveness. It is found that: (1) The internationalization of western central-cities has a positive and direct impact on the promotion of urban competitiveness, which has a significant impact on economic strength and infrastructure, and a weak impact on government efficiency and market efficiency The marginal growth effect of internationalization on urban scale will gradually decrease with the improvement of urban development level. (2) The continuous promotion of city internationalization can promote the innovation ability to enhance the competitiveness of the city. Compared with the internationalization of cities, the influence of innovation ability on the competitiveness of cities is small, and the innovation ability of western central-cities and each city is weak. The scale effect has become the main motivation to promote the competitiveness of cities. (3) In the process of internationalization of western central-cities, innovation ability has a part of intermediary effect on the improvement of urban competitiveness, and the effect on urban “hard environment” is significantly greater than that on urban “Soft-environment”. The results of direct and indirect impact tests show that the impact of the process of internationalization of western central-cities on urban competitiveness is exogenous.