Open Access Review

Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects

by Hongmei Yang a,1 orcid Chen Li b,1 orcid  and  Qiang Xie c,* orcid
a
Department of Biological Engineering and Chemistry, and Center for Environmental Health Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
b
Department of Biology, Chemistry, Pharmacy, Free University of Berlin, 14195, Berlin, Germany.
c
Department of Vascular Interventional Radiology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.
*
Author to whom correspondence should be addressed.
CI  2023, 20; 2(2), 20; https://doi.org/10.58567/ci02020004
Received: 5 June 2023 / Accepted: 13 June 2023 / Published: 28 June 2023

Abstract

Nanomaterials have shown great potential in anti-tumor applications and are currently the focus of research. This review article aims to provide a comprehensive overview of the challenges encountered in oncology treatment and how nanomaterials are being utilized to overcome these obstacles. The authors discuss the limitations of conventional treatments, including limited efficacy, side effects, and toxicity issues. They highlight the importance of early tumour diagnosis and personalized treatment plans, as well as the need for innovative therapeutic approaches such as targeted therapy, immunotherapy, and gene therapy. The article primarily focuses on how nanomaterials can be engineered to achieve specific recognition and aggregation within tumour tissues through surface modifications involving targeting molecules such as antibodies, peptides, and receptor ligands. This surface modification technique facilitates improved targeting in the targeting of photodynamic therapy, while minimizing harm to normal tissues. The authors also discuss the potential and future prospects of nanomaterials in tumour therapy, including breakthroughs in their application, biosafety concerns, biocompatibility issues, preparation processes, clinical translation challenges, interdisciplinary cooperation, international exchange, relevant regulations and ethical guidelines. Overall, this review highlights the substantial potential of nanomaterials in oncology treatment, emphasizing the need for careful consideration of safety concerns to ensure their safe and effective application. The authors conclude that strengthening interdisciplinary cooperation and international exchange will contribute to the healthy development of nanomaterials in oncology treatment.


Copyright: © 2023 by Yang, Li and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Show Figures

Share and Cite

ACS Style
Yang, H.; Li, C.; Xie, Q. Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight, 2023, 2, 20. https://doi.org/10.58567/ci02020004
AMA Style
Yang H, Li C, Xie Q. Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight; 2023, 2(2):20. https://doi.org/10.58567/ci02020004
Chicago/Turabian Style
Yang, Hongmei; Li, Chen; Xie, Qiang 2023. "Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects" Cancer Insight 2, no.2:20. https://doi.org/10.58567/ci02020004
APA style
Yang, H., Li, C., & Xie, Q. (2023). Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight, 2(2), 20. https://doi.org/10.58567/ci02020004

Article Metrics

Article Access Statistics

References

  1. LIU J, PANDYA P, AFSHAR S.Therapeutic Advances in Oncology. Int J Mol Sci, 2021, 22 (4).
  2. ASSARAF Y G, BROZOVIC A, GONçALVES A C, et al.The multi-factorial nature of clinical multidrug resistance in cancer. Drug Resist Updat, 2019, 46: 100645.
  3. CHENG Z, LI M, DEY R, et al.Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol, 2021, 14 (1): 85.
  4. FAROKHZAD O C, LANGER R.Impact of nanotechnology on drug delivery. ACS Nano, 2009, 3 (1): 16-20.
  5. WANG Z, TANG L, MU Q, et al.Engineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment. Curr Med Chem, 2021, 28 (31): 6395-6410.
  6. KUMBHAR P, KOLE K, KHADAKE V, et al.Nanoparticulate drugs and vaccines: Breakthroughs and bottlenecks of repurposing in breast cancer. J Control Release, 2022, 349: 812-830.
  7. LIU J, HE S, LUO Y, et al.Tumor-Microenvironment-Activatable Polymer Nano-Immunomodulator for Precision Cancer Photoimmunotherapy. Advanced Materials, 2022, 34 (8): e2106654.
  8. SHI J, KANTOFF P W, WOOSTER R, et al.Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer, 2017, 17 (1): 20-37.
  9. PRAMANIK A, VANGARA A, VIRAKA NELLORE B P, et al.Development of Multifunctional Fluorescent-Magnetic Nanoprobes for Selective Capturing and Multicolor Imaging of Heterogeneous Circulating Tumor Cells. ACS Appl Mater Interfaces, 2016, 8 (24): 15076-15085.
  10. ZHANG Y, LI M, GAO X, et al.Nanotechnology in cancer diagnosis: progress, challenges and opportunities. J Hematol Oncol, 2019, 12 (1): 137.
  11. MABROUK M, DAS D B, SALEM Z A, et al.Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties. Molecules, 2021, 26 (4):
  12. YOHAN D, CHITHRANI B D.Applications of nanoparticles in nanomedicine. J Biomed Nanotechnol, 2014, 10 (9): 2371-2392.
  13. HAIDAR M K, EROGLU H.Nanofibers: New Insights for Drug Delivery and Tissue Engineering. Current Topics in Medicinal Chemistry, 2017, 17 (13): 1564-1579.
  14. WANG K, LIU Y, WANG H, et al.Multi-functional nanofilms capable of angiogenesis, near-infrared-triggered anti-bacterial activity and inflammatory regulation for infected wound healing. Biomater Adv, 2022, 142: 213154.
  15. THOMMES M, SCHLUMBERGER C.Characterization of Nanoporous Materials. Annu Rev Chem Biomol Eng, 2021, 12: 137-162.
  16. WU X, YANG H, CHEN X, et al.Nano-herb medicine and PDT induced synergistic immunotherapy for colon cancer treatment. Biomaterials, 2021, 269: 120654.
  17. BANERJEE S, PILLAI J.Solid lipid matrix mediated nanoarchitectonics for improved oral bioavailability of drugs. Expert Opin Drug Metab Toxicol, 2019, 15 (6): 499-515.
  18. GUO Y, SHEN Y, YU B, et al.Hydrophilic Poly(glutamic acid)-Based Nanodrug Delivery System: Structural Influence and Antitumor Efficacy. Polymers (Basel), 2022, 14 (11):
  19. JENKINS S V, NIMA Z A, VANG K B, et al.Triple-negative breast cancer targeting and killing by EpCAM-directed, plasmonically active nanodrug systems. NPJ Precis Oncol, 2017, 1 (1): 27.
  20. WANG C, LI F, ZHANG T, et al.Recent advances in anti-multidrug resistance for nano-drug delivery system. Drug Deliv, 2022, 29 (1): 1684-1697.
  21. HUANG Y, ZHU Y, CAI D, et al.Penetrating-peptide-mediated non-invasive Axitinib delivery for anti-neovascularisation. J Control Release, 2022, 347: 449-459.
  22. DING D, ZHONG H, LIANG R, et al.Multifunctional Nanodrug Mediates Synergistic Photodynamic Therapy and MDSCs-Targeting Immunotherapy of Colon Cancer. Adv Sci (Weinh), 2021, 8 (14): e2100712.
  23. BALAKRISHNAN P B, LEDEZMA D K, CANO-MEJIA J, et al.CD137 agonist potentiates the abscopal efficacy of nanoparticle-based photothermal therapy for melanoma. Nano Res, 2022, 15 (3): 2300-2314.
  24. LIU Y, WANG L, SONG Q, et al.Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion. Nat Nanotechnol, 2022, 17 (2): 206-216.
  25. BAI S, LU Z, JIANG Y, et al.Nanotransferrin-Based Programmable Catalysis Mediates Three-Pronged Induction of Oxidative Stress to Enhance Cancer Immunotherapy. ACS Nano, 2022, 16 (1): 997-1012.
  26. CHEN M, GONG N, SUN W, et al.Red-Light-Responsive Metallopolymer Nanocarriers with Conjugated and Encapsulated Drugs for Phototherapy Against Multidrug-Resistant Tumors. Small, 2022, 18 (27): e2201672.
  27. LEACH A, SMYTH P, FERGUSON L, et al.Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature. Nanoscale, 2020, 12 (27): 14751-14763.
  28. CREEMERS J H A, PAWLITZKY I, GROSIOS K, et al.Assessing the safety, tolerability and efficacy of PLGA-based immunomodulatory nanoparticles in patients with advanced NY-ESO-1-positive cancers: a first-in-human phase I open-label dose-escalation study protocol. BMJ Open, 2021, 11 (11): e050725.
  29. CARSON C S, BECKER K W, GARLAND K M, et al.A nanovaccine for enhancing cellular immunity via cytosolic co-delivery of antigen and polyIC RNA. J Control Release, 2022, 345: 354-370.
  30. LIU Y, ZHAO G, XU C F, et al.Systemic delivery of CRISPR/Cas9 with PEG-PLGA nanoparticles for chronic myeloid leukemia targeted therapy. Biomater Sci, 2018, 6 (6): 1592-1603.
  31. HU R, ZHENG M, WU J, et al.Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer. Nanomaterials (Basel), 2017, 7 (5):
  32. LI B, NIU X, XIE M, et al.Tumor-Targeting Multifunctional Nanoprobe for Enhanced Photothermal/Photodynamic Therapy of Liver Cancer. Langmuir, 2021, 37 (27): 8064-8072.
  33. ZHANG Y, ZHOU T, LI J, et al.Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy. Int J Nanomedicine, 2021, 16: 2501-2513.
  34. SHEN W, ZHANG X, LIU D, et al.A Photothermal Therapy Strategy for Monitoring Real-Time Temperature in Kidney Cancers by Injecting Gold Nanorods with Phosphors. J Biomed Nanotechnol, 2021, 17 (3): 501-508.
  35. PHUA S Z F, YANG G, LIM W Q, et al.Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor. ACS Nano, 2019, 13 (4): 4742-4751.
  36. LI W, YANG J, LUO L, et al.Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death. Nat Commun, 2019, 10 (1): 3349.
  37. CABRAL Á S, LEONEL E C R, CANDIDO N M, et al.Combined photodynamic therapy with chloroaluminum phthalocyanine and doxorubicin nanoemulsions in breast cancer model. J Photochem Photobiol B, 2021, 218: 112181.
  38. HU L, CHEN Z, LIU Y, et al.In Vivo Bioimaging and Photodynamic Therapy Based on Two-Photon Fluorescent Conjugated Polymers Containing Dibenzothiophene-S,S-dioxide Derivatives. ACS Appl Mater Interfaces, 2020, 12 (51): 57281-57289.
  39. XIE J, WANG Y, CHOI W, et al.Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies. Chemical Society Reviews, 2021, 50 (16): 9152-9201.
  40. CHEN Y, YANG J, FU S, et al.Gold Nanoparticles as Radiosensitizers in Cancer Radiotherapy. Int J Nanomedicine, 2020, 15: 9407-9430.
  41. GUAN X, SUN L, SHEN Y, et al.Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis. Nat Commun, 2022, 13 (1): 2834.
  42. ZHANG S, ZHANG Y, FENG Y, et al.Biomineralized Two-Enzyme Nanoparticles Regulate Tumor Glycometabolism Inducing Tumor Cell Pyroptosis and Robust Antitumor Immunotherapy. Advanced Materials, 2022, 34 (50): e2206851.
  43. LIU J N, BU W, SHI J.Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia. Chemical Reviews (Washington, DC, United States), 2017, 117 (9): 6160-6224.
  44. COGOI S, JAKOBSEN U, PEDERSEN E B, et al.Lipid-modified G4-decoy oligonucleotide anchored to nanoparticles: delivery and bioactivity in pancreatic cancer cells. Sci Rep, 2016, 6: 38468.
  45. EYCHENNE R, BOUVRY C, BOURGEOIS M, et al.Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy. Molecules, 2020, 25 (17):
  46. ROY I, KRISHNAN S, KABASHIN A V, et al.Transforming Nuclear Medicine with Nanoradiopharmaceuticals. ACS Nano, 2022, 16 (4): 5036-5061.
  47. WANG L, CAO Y, ZHANG X, et al.Reactive oxygen species-responsive nanodrug of natural crocin-i with prolonged circulation for effective radioprotection. Colloids Surf B Biointerfaces, 2022, 213: 112441.
  48. POLYAK A, ROSS T L.Nanoparticles for SPECT and PET Imaging: Towards Personalized Medicine and Theranostics. Curr Med Chem, 2018, 25 (34): 4328-4353.
  49. PEI Q, LU S, ZHOU J, et al.Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy. ACS Appl Mater Interfaces, 2021, 13 (50): 59708-59719.
  50. JAIDEV L R, BHAVSAR D V, SHARMA U, et al.Engineered multifunctional nanomaterials for multimodal imaging of retinoblastoma cells in vitro. J Biomater Sci Polym Ed, 2014, 25 (11): 1093-1109.
  51. ZHOU T, LIANG X, WANG P, et al.A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence. ACS Nano, 2020, 14 (10): 12679-12696.
  52. YAN R, HU Y, LIU F, et al.Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly. Journal of the American Chemical Society, 2019, 141 (26): 10331-10341.
  53. SHAO H, CHUNG J, BALAJ L, et al.Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med, 2012, 18 (12): 1835-1840.
  54. VISWAMBARI DEVI R, DOBLE M, VERMA R S.Nanomaterials for early detection of cancer biomarker with special emphasis on gold nanoparticles in immunoassays/sensors. Biosensors and Bioelectronics, 2015, 68: 688-698.
  55. BAI H, WANG Y, HU Y, et al.A caspase-3-activatable bimodal probe for photoacoustic and magnetic resonance imaging of tumor apoptosis in vivo. Biosensors and Bioelectronics, 2022, 216: 114648.
  56. CHEN X, LI J, HUANG Y, et al.The biodistribution, excretion and potential toxicity of different-sized Pd nanosheets in mice following oral and intraperitoneal administration. Biomater Sci, 2017, 5 (12): 2448-2455.
  57. JIANG Z, ZHANG W, ZHANG J, et al.Nanomaterial-Based Drug Delivery Systems: A New Weapon for Cancer Immunotherapy. Int J Nanomedicine, 2022, 17: 4677-4696.
  58. CHEN J, YE Z, HUANG C, et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8(+) T cell response. Proc Natl Acad Sci U S A, 2022, 119 (34): e2207841119.
  59. MIRSHAFIEE V, JIANG W, SUN B, et al.Facilitating Translational Nanomedicine via Predictive Safety Assessment. Mol Ther, 2017, 25 (7): 1522-1530.
  60. XIONG X, ZHAO J, PAN J, et al.Personalized Nanovaccine Coated with Calcinetin-Expressed Cancer Cell Membrane Antigen for Cancer Immunotherapy. Nano Letters, 2021, 21 (19): 8418-8425.
  61. NGUYEN P V, ALLARD-VANNIER E, CHOURPA I, et al.Nanomedicines functionalized with anti-EGFR ligands for active targeting in cancer therapy: Biological strategy, design and quality control. International Journal of Pharmaceutics, 2021, 605: 120795.
  62. VILOS C, MORALES F A, SOLAR P A, et al.Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells. Biomaterials, 2013, 34 (16): 4098-4108.
  63. KHOOBCHANDANI M, KATTI K K, KARIKACHERY A R, et al.New Approaches in Breast Cancer Therapy Through Green Nanotechnology and Nano-Ayurvedic Medicine - Pre-Clinical and Pilot Human Clinical Investigations. Int J Nanomedicine, 2020, 15: 181-197.
  64. JI C, SI J, XU Y, et al.Mitochondria-targeted and ultrasound-responsive nanoparticles for oxygen and nitric oxide codelivery to reverse immunosuppression and enhance sonodynamic therapy for immune activation. Theranostics, 2021, 11 (17): 8587-8604.
  65. RILEY R S, DAY E S.Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2017, 9 (4):
  66. ZOU H, LI M, LI X, et al.Multimodal imaging and photothermal synergistic immunotherapy of retinoblastoma with tuftsin-loaded carbonized MOF nanoparticles. Drug Deliv, 2022, 29 (1): 1785-1799.
  67. SHI Y, LAMMERS T.Combining Nanomedicine and Immunotherapy. Accounts of Chemical Research, 2019, 52 (6): 1543-1554.
  68. XU X, LIU C, WANG Y, et al.Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment. Adv Drug Deliv Rev, 2021, 176: 113891.
  69. MORADI KASHKOOLI F, SOLTANI M, SOURI M.Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies. J Control Release, 2020, 327: 316-349.
  70. AIKINS M E, XU C, MOON J J.Engineered Nanoparticles for Cancer Vaccination and Immunotherapy. Accounts of Chemical Research, 2020, 53 (10): 2094-2105.
  71. SOHRABI M, BABAEI Z, HAGHPANAH V, et al.Recent advances in gene therapy-based cancer monotherapy and synergistic bimodal therapy using upconversion nanoparticles: Structural and biological aspects. Biomed Pharmacother, 2022, 156: 113872.
  72. GAO X, ZHANG J, HE Z, et al.Targeting delivery of synergistic dual drugs with elastic PEG-modified multi-functional nanoparticles for hepatocellular carcinoma therapy. International Journal of Pharmaceutics, 2022, 616: 121567.
  73. FU B, LIN H C, LIU Y C, et al.VEGF aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research. Journal of Biomaterials Applications, 2022, 36 (7): 1277-1288.
  74. CHEN Q, LI C, WANG Q.Multifunctional Nano-Biomaterials for Cancer Therapy via Inducing Enhanced Immunogenic Cell Death. Small Methods, 2023: e2201457.
  75. LI H, CAI X, YI T, et al.Tumor microenvironment responsive Mn(3)O(4) nanoplatform for in vivo real-time monitoring of drug resistance and photothermal/chemodynamic synergistic therapy of gastric cancer. J Nanobiotechnology, 2022, 20 (1): 240.
  76. AGARWALLA P, OGUNNAIKE E A, AHN S, et al.Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells. Nature Biotechnology, 2022, 40 (8): 1250-1258.
  77. XIAO Y, CHEN J, ZHOU H, et al.Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the immune microenvironment for effective cancer therapy. Nat Commun, 2022, 13 (1): 758.