Open Access Journal Article

Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells

by Chao Liu a Qin Qin a  and  Hongliang Cong b,*
Institute of Cardiovascular Diseases, Chest Hospital, Tianjin University, Tianjin, 300222, China.
Department of Cardiology, Chest Hospital, Tianjin University, Tianjin, 300222, China.
Author to whom correspondence should be addressed.
CI  2022, 8; 1(1), 8;
Received: 1 June 2022 / Accepted: 16 June 2022 / Published Online: 20 June 2022


Lung cancer is the leading cause of cancer-related deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers, and lung adenocarcinoma is the most common NSCLC. Most patients with lung cancer eventually lead to local and metastatic recurrence, including many patients who have completely removed the primary tumor during surgery and have no noticeable metastasis. There are two different deoxynucleotide triphosphate (dNTP) libraries in eukaryotic cells. The de novo synthesis of dNTPs in the cytoplasm is coordinated with the cell cycle and reaches a peak in the S phase, thereby providing deoxynucleotides for the replication of genomic DNA. In contrast, the mitochondrial pool of dNTPs is maintained through the mitochondrial deoxynucleoside rescue pathway throughout the cell cycle and is essential for mtDNA replication. Mitochondria are vital cell powers in assimilation and catabolism. Oxidative phosphorylation (OXPHOS) of mitochondria is essential for the self-renewal of cancer stem-like cells in lung cancer, glioblastoma and leukemia. Thymidine kinase 2 (TK2) and deoxyguanosine kinase (DGUOK) are two mitochondrial deoxynucleoside kinases, which are responsible for the transport of pyrimidine and purine deoxynucleoside in mitochondria. Apoptosis and autophagy are important processes that regulate cell proliferation and death in normal cells and cancer cells. Inducing cancer cell apoptosis and autophagy is an effective means to treat malignant tumors. This review discusses the research progress of the relationship between mitochondrial deoxyguanosine kinase and lung adenocarcinoma cell apoptosis and autophagy.

Copyright: © 2022 by Liu, Qin and Cong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Liu, C.; Qin, Q.; Cong, H. Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight, 2022, 1, 8.
AMA Style
Liu C, Qin Q, Cong H. Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight; 2022, 1(1):8.
Chicago/Turabian Style
Liu, Chao; Qin, Qin; Cong, Hongliang 2022. "Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells" Cancer Insight 1, no.1:8.
APA style
Liu, C., Qin, Q., & Cong, H. (2022). Research Progress on the Relationship Between Mitochondrial Deoxyguanosine Kinase and Apoptosis and Autophagy in Lung Adenocarcinoma Cells. Cancer Insight, 1(1), 8.

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  1. e. J Mol Cell Ca1. Zhong Y, Yi T. MoS(2) quantum dots as a unique fluorescent "turn-off-on" probe for the simple and rapid determination of adenosine triphosphate. J Mater Chem B, 2019, 7(15):2549-2556.
  2. Sedman T, Garber N, Gaidutšik I, et al. Mitochondrial helicase Irc3 translocates along double-stranded DNA. FEBS Lett, 2017, 591(23):3831-3841.
  3. Zheng Y, Zhang DY, Zhang H, et al. Photodamaging of Mitochondrial DNA to Overcome Cisplatin Resistance by a Ru(II) -Pt(II) Bimetallic Complex. Chemistry, 2018, 24(71):18971-18980.
  4. Nissanka N, Moraes CT. Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. FEBS Lett, 2018, 592(5):728-742.
  5. Xia CY, Liu Y, Yang HR, et al. Reference Intervals of Mitochondrial DNA Copy Number in Peripheral Blood for Chinese Minors and Adults. Chin Med J (Engl), 2017, 130(20):2435-2440.
  6. Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature, 2018, 553(7689):446-454.
  7. Liu Y, Davis AS, Ma L, et al. MUC1 mediates Pneumocystis murina binding to airway epithelial cells. Cell Microbiol, 2020, 22(6):e13182.
  8. van Schaardenburgh M, Wohlwend M, Rognmo Ø, et al. Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function. J Transl Med, 2017, 15(1):130.
  9. Vergeade A, Bertram CC, Bikineyeva AT, et al. Cardiolipin fatty acid remodeling regulates mitochondrial function by modifying the electron entry point in the respiratory chain . Mitochondrion, 2016, 28(5):88-95.
  10. Binder NK, Sheedy JR, Hannan NJ, et al. Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model . Mol Hum Reprod, 2015, 21(5):424-34.
  11. Lehmann D, Tuppen HAL, Campbell GE, et al. Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level. Nucleic Acids Res, 2019, 47(14):7430-7443.
  12. Rahman S, Copeland WC, et al. POLG-related disorders and their neurological manifestations. Nat Rev Neurol, 2019, 15(1):40-52.
  13. Zhao L. Mitochondrial DNA degradation: A quality control measure for mitochondrial genome maintenance and stress response. Enzymes, 2018, 45: 311-341.
  14. Foote K, Reinhold J, Yu EPK, et al. Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice. Aging Cell, 2018, 17(4):e12773.
  15. Lutu MR, Nzuza S, Mofo Mato PE, et al. DNA polymerase-gamma hypothesis in nucleoside reverse transcriptase-induced mitochondrial toxicity revisited: A potentially protective role for citrus fruit-derived naringenin. Eur J Pharmacol, 2019, 852(6):159-166.
  16. Kjær IM, Olsen DA, Alnor A, et al. EGFR and EGFR ligands in serum in healthy women; reference intervals and age dependency. Clin Chem Lab Med, 2019, 57(12):1948-1955.
  17. von Achenbach C, Weller M, Szabo E. Epidermal growth factor receptor and ligand family expression and activity in glioblastoma. J Neurochem, 2018, 147(1): 99-109.
  18. Cinats A, Heck E, Robertson L. Janus Kinase Inhibitors: A Review of Their Emerging Applications in Dermatology. Skin Therapy Lett, 2018, 23(3):5-9.
  19. Banerjee S, Biehl A, Gadina M, et al. JAK-STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects. Drugs, 2017, 77(5):521-546.
  20. Howell MD, Kuo FI, Smith PA. Targeting the Janus Kinase Family in Autoimmune Skin Diseases. Front Immunol, 2019, 10(10):2342.
  21. Hartwig T, Montinaro A, von Karstedt S, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell, 2017, 65(4):730-742.e5.
  22. Ozyerli-Goknar E, Sur-Erdem I, Seker F, et al. The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma. Cell Death Dis, 2019, 10(12):894.
  23. Li Y, Xia J, Jiang N, et al. Corin protects H(2)O(2)-induced apoptosis through PI3K/AKT and NF-kappaB pathway in cardiomyocytes. Biomed Pharmacother, 2018, 97(1):594-599.
  24. Jin Y, Qiu S, Shao N, et al. Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-kappaB Signaling Pathway. Med Sci Monit, 2018, 24(1):11-18.
  25. Li M, Ye J, Zhao G, et al. Gas6 attenuates lipopolysaccharide-induced TNF-alpha expression and apoptosis in H9C2 cells through NF-kappaB and MAPK inhibition via the Axl/PI3K/Akt pathway. Int J Mol Med, 2019, 44(3):982-994.
  26. He J, Fu L, Li Q. Rsf-1 regulates malignant melanoma cell viability and chemoresistance via NF-kappaB/Bcl-2 signaling. Mol Med Rep, 2019, 20(4): 3487- 3498.
  27. Zhang Y, Xia M, Jin K, et al. Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities. Mol Cancer, 2018, 17(1):45.
  28. Baumgartner U, Berger F, Hashemi Gheinani A, et al. miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Mol Cancer, 2018, 17(1):44.
  29. Rosanna T Micale, Sebastiano La Maestra, Angela Di Pietro, et al. Oxidative stress in the lung of mice exposed to cigarette smoke either early in life or in adulthood. Arch Toxicol, 2013, 87(5):915-918.
  30. Dong Y, Chen H, Gao J, et al. Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease. J Mol Cell Cardiol, 2019, 136(11):27-41.rdiol, 2019, 136(11):27-41.