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Articles ( Showing 1-20 of 5 items)
Searched for: [ Keywords: "Long noncoding RNAs (lncRNAs)" ] clear all
Journal Article
How Does Lncrna Regulation Impact Cancer Metastasis
by Abreto Devit Mancheng  and  Ugwemubwem Ossas
Abstract
Metastasis is the major cause of cancer-related mortality. Metastasis is a process through which cancer spreads from its initial location to other sections of the body. Cancer cells' epithelial-mesenchymal transition (EMT), anoikis resistance, cell migration, and angiogenesis are all well-known steps in this process. Investigating the molecular processes that govern cancer meta [...] Read more

Journal Article
A prognostic aging-related lncRNA risk model correlates with the immune microenvironment in HCC
by Kun Mei , Zilu Chen , Qin Wang , Akbar Ali , Yan Huang  and  Luo Yi
Abstract
Background: Hepatocellular carcinoma (HCC) stands out as one of the most lethal cancers globally, given its complexity, recurrence following surgical resection, metastatic potential, and inherent heterogeneity. In recent years, researchers have systematically elucidated the significance of long non-coding RNA (lncRNA) in the initiation and progression of HCC. The intr [...] Read more

Review
Cell membrane-coated nanoparticles for cancer therapy
by Yasir Hameed , Mohsen Nabi-Afjadi , Yuan Gu  and  Long Wu
Abstract
Despite the advantages of nanoscale drug delivery systems, traditional nanoparticles often encounter challenges such as detection and elimination by the immune system. To circumvent these limitations, scientists have created biomimetic nanoparticles that extend circulation time, decrease clearance rates, and optimize drug delivery. The integration of cell membranes onto nanopar [...] Read more

Journal Article
The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression
by Haitao Chen , Huilong Li , Wanjin Shi , Hai Qin  and  Lufeng Zheng
Abstract
As a reversible post-transcriptional modification, N6-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a subpopulation of cells with self-renewal ability and differentiation potential, have been regarded to be one of the roots of tumor occurrence, recurrence, and metastasis. Currently, numerous studies have dem [...] Read more

Journal Article
Comprehensive analyses reveal molecular and clinical characteristics of RNA modification writers across 32 cancer types
by Jiayu Ding , Hao Shen , Jiaying Ji , Jiaxing Li , Wenbin Kuang , Zhongrui Shi , Dawei Wang , Yuanyuan Chen , Didi Wan , Xiao Wang  and  Peng Yang
Abstract
Adenosine alterations to RNA, which are largely determined by RNA modification writers (RMWs), are critical for cancer growth and progression. These RMWs can catalyze different types of adenosine modifications, such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), alternative polyadenylation (APA), and adenosine-to-inosine (A-to-I) RNA editing. These modifications have pr [...] Read more