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Open Access Journal Article

Polymers containing natural plant phenolic compounds for peripheral nerve injury

by Tong Zheng a,b Shuoke Qiu b Lei Li a,b Binglong Li a,b  and  Meng Zhang c,*
Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, 250012 Shandong, China
Shandong University Cheeloo College of Medicine, Jinan, 250100 Shandong, China
Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, China
Author to whom correspondence should be addressed.
BAB  2022, 4; 1(1), 4;
Received: 15 November 2022 / Accepted: 5 December 2022 / Published Online: 26 December 2022


Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy,chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.

Copyright: © 2022 by Zheng, Qiu, Li, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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The Horizontal project of Shandong University (12671818) , The Rongxiang Regenerative Medicine Foundation of Shandong University (2019SDRX-17)

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ACS Style
Zheng, T.; Qiu, S.; Li, L.; Li, B.; Zhang, M. Polymers containing natural plant phenolic compounds for peripheral nerve injury. Biomaterials and Biosensors, 2022, 1, 4.
AMA Style
Zheng T, Qiu S, Li L, Li B, Zhang M. Polymers containing natural plant phenolic compounds for peripheral nerve injury. Biomaterials and Biosensors; 2022, 1(1):4.
Chicago/Turabian Style
Zheng, Tong; Qiu, Shuoke; Li, Lei; Li, Binglong; Zhang, Meng 2022. "Polymers containing natural plant phenolic compounds for peripheral nerve injury" Biomaterials and Biosensors 1, no.1:4.
APA style
Zheng, T., Qiu, S., Li, L., Li, B., & Zhang, M. (2022). Polymers containing natural plant phenolic compounds for peripheral nerve injury. Biomaterials and Biosensors, 1(1), 4.

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