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Searched for: [ Keywords: "MTDH" ] clear all
Review
Overcoming MTDH and MTDH-SND1 complex: driver and potential therapeutic target of cancer
by Hao Shen , Jiayu Ding , Jiaying Ji , Binjian Jiang , Xiao Wang  and  Peng Yang
Abstract
Metadherin (MTDH), also known as LYRIC or AEG-1, is an oncogene that enhances tumor progression, metastasis, drug resistance, and immune escape in various cancers by modulating multiple oncogenic pathways, including NF-κB, PI3K/AKT, Wnt/β-catenin, MAPK, and AMPK. Due to the unknown of the complete structure of MTDH, the deep mechanisms of MTDH and selective inhibitor [...] Read more