Open Access Journal Article

Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications

by Xingru Zhao a,b ,  Qi An b,*  and  Jingwen Cai c,*
a
Beijing CapitalBio Technology Co., Ltd, Beijing 101111, China
b
State Key Laboratory of Tribology in Advanced Equipment, Tsinghua University, Beijing 100084, China
c
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
*
Author to whom correspondence should be addressed.
CI  2022, 14; 1(2), 14; https://doi.org/10.58567/ci01020005
Received: 2 December 2022 / Accepted: 15 December 2022 / Published Online: 22 December 2022
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Abstract

Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydroxides. It has a series of unique properties, such as high conductivity, metalloid properties, a variety of valence states and adjustable structure and so on. These advantages make it have great potential in biomedical applications, such as diagnostic imaging, disease therapy and drug/gene delivery. This review presents the latest research progress of TMS/TMP on tumor imaging, diagnosis and treatment. Here, we first illustrate the synthesis approaches and surface modification of TMS/TMP. Then, its emerging applications in tumor diagnosis and therapy are highlighted. Moreover, the challenges of TMS/TMP-mediated diagnosis/treat are provided and the prospective for this field are discussed.

Keywords: Transition metal sulfides; Transition metal phosphides; Nanomedicine; Drug delivery; Cancer diagnosis and therapy;
Copyright: © 2022 by Zhao, An and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.