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Overcoming the challenge: cell-penetrating peptides and membrane permeability

by Yuan Gu a,1 orcid Long Wu b,1 orcid Yasir Hameed c,* orcid  and  Mohsen Nabi-Afjadi d,* orcid
The Statistics Department, The George Washington University, Washington, United States
Department of Surgery, University of Maryland, Baltimore, United States
Department of Applied Biological Sciences, Tokyo University of Science, Tokyo, Japan
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Author to whom correspondence should be addressed.
BAB  2023, 7; 2(1), 7;
Received: 15 June 2023 / Accepted: 28 June 2023 / Published Online: 29 June 2023


Cell-penetrating peptides (CPPs) have emerged as a promising strategy for enhancing the membrane permeability of bioactive molecules, particularly in the treatment of central nervous system diseases. CPPs possess the ability to deliver a diverse array of bioactive molecules into cells using either covalent or non-covalent approaches, with a preference for non-covalent methods to preserve the biological activity of the transported molecules. By effectively traversing various physiological barriers, CPPs have exhibited significant potential in preclinical and clinical drug development. The discovery of CPPs represents a valuable solution to the challenge of limited membrane permeability of bioactive molecules and will continue to exert a crucial influence on the field of biomedical science.

Copyright: © 2023 by Gu, Wu, Hameed and Nabi-Afjadi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Gu, Y.; Wu, L.; Hameed, Y.; Nabi-Afjadi, M. Overcoming the challenge: cell-penetrating peptides and membrane permeability. Biomaterials and Biosensors, 2023, 2, 7.
AMA Style
Gu Y, Wu L, Hameed Y, Nabi-Afjadi M. Overcoming the challenge: cell-penetrating peptides and membrane permeability. Biomaterials and Biosensors; 2023, 2(1):7.
Chicago/Turabian Style
Gu, Yuan; Wu, Long; Hameed, Yasir; Nabi-Afjadi, Mohsen 2023. "Overcoming the challenge: cell-penetrating peptides and membrane permeability" Biomaterials and Biosensors 2, no.1:7.
APA style
Gu, Y., Wu, L., Hameed, Y., & Nabi-Afjadi, M. (2023). Overcoming the challenge: cell-penetrating peptides and membrane permeability. Biomaterials and Biosensors, 2(1), 7.

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