Open Access Review

Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects

by Hongmei Yang a,1 orcid Chen Li b,1 orcid  and  Qiang Xie c,* orcid
Department of Biological Engineering and Chemistry, and Center for Environmental Health Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Biology, Chemistry, Pharmacy, Free University of Berlin, 14195, Berlin, Germany.
Department of Vascular Interventional Radiology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630, China.
Author to whom correspondence should be addressed.
Received: 5 June 2023 / Accepted: 13 June 2023 / Published: 28 June 2023


Nanomaterials have shown great potential in anti-tumor applications and are currently the focus of research. This review article aims to provide a comprehensive overview of the challenges encountered in oncology treatment and how nanomaterials are being utilized to overcome these obstacles. The authors discuss the limitations of conventional treatments, including limited efficacy, side effects, and toxicity issues. They highlight the importance of early tumour diagnosis and personalized treatment plans, as well as the need for innovative therapeutic approaches such as targeted therapy, immunotherapy, and gene therapy. The article primarily focuses on how nanomaterials can be engineered to achieve specific recognition and aggregation within tumour tissues through surface modifications involving targeting molecules such as antibodies, peptides, and receptor ligands. This surface modification technique facilitates improved targeting in the targeting of photodynamic therapy, while minimizing harm to normal tissues. The authors also discuss the potential and future prospects of nanomaterials in tumour therapy, including breakthroughs in their application, biosafety concerns, biocompatibility issues, preparation processes, clinical translation challenges, interdisciplinary cooperation, international exchange, relevant regulations and ethical guidelines. Overall, this review highlights the substantial potential of nanomaterials in oncology treatment, emphasizing the need for careful consideration of safety concerns to ensure their safe and effective application. The authors conclude that strengthening interdisciplinary cooperation and international exchange will contribute to the healthy development of nanomaterials in oncology treatment.

Copyright: © 2023 by Yang, Li and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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ACS Style
Yang, H.; Li, C.; Xie, Q. Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight, 2023, 2, 20.
AMA Style
Yang H, Li C, Xie Q. Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight; 2023, 2(1):20.
Chicago/Turabian Style
Yang, Hongmei; Li, Chen; Xie, Qiang 2023. "Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects" Cancer Insight 2, no.1: 20.
APA style
Yang, H., Li, C., & Xie, Q. (2023). Advances in the Use of Nanomaterials in Tumour Therapy: Challenges and Prospects. Cancer Insight, 2(1), 20.

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